Targeting transcription and chromatin deregulation in cancer.
MYC in cancer
Understanding how this devastating oncogenic transcription factor reshapes tumor gene expression programs
See Lin et al., Cell 2012, Wolf et al., TICB 2014, and Zeid et al., Nat. Genetics 2018
Therapeutics of Gene control
We are excited to be part of the new Therapeutic Innovation Center at BCM to drive experimental therapeutics in diseases of altered gene regulation.
Computational Biology
Modeling of transcription factor networks and enhancer regulation in cancer and cardiovascular disease
Chemical Biology
Using selective inhibitors of transcription and chromatin to modulate cell state
See Loven et al., Cell 2013, Anand et al., Cell 2013, Brown et al., Mol. Cell 2014, and Shu et al., Nature 2016
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